![]() Hopefully, the wait will not be a long one. Newman says, “Although we’ve identified this highly unusual protein as only existing in monotremes, this discovery increases our knowledge of protein structures in general, and will go on to inform other drug discovery work done at the Centre.”įor now, we will have to wait and see how this new protein might be unleashed in the war against antibiotic resistance. Shirley Temple may open the door to other fields of study, too Dr. This, perhaps, is the reason that platypus milk needs to be so profoundly antibacterial. Of course, this opens the young animals up to an unholy array of bacteria and other nasties. But as I was saying, since there are no teets, the mother’s milk comes into contact with the outside world, and the baby platypus must lick the milk from the surrounding hair. I’ll stick with baby platypuses for the sake of maintaining some degree of scientific integrity. So, without nipples, the mother platypus secretes milk from a patch of skin.Īs an aside, baby platypuses - rather boringly - are officially called “baby platypuses.” However, there are more pleasing, if unofficial, names, including puggles and platypups, so feel free to use whichever you deem cutest. Unlike the vast majority of mammals, the platypus has no nipples (which is yet another reason why platypuses are considered one of planet Earth’s oddest residents). “Platypus are such weird animals that it would make sense for them to have weird biochemistry.” The intriguing format of the protein has not been seen in nature before. The protein has a ringlet-like formation, thus earning it the nickname Shirley Temple. ![]() The magical, bacteria-slaughtering capabilities of the milk protein might come from its unique 3-D folding. Achieving this feat took the combined might of the Synchrotron, a cyclic particle accelerator, and the CSIRO’s ultra-hi-tech Collaborative Crystallisation Centre. Recreating a protein in the laboratory sounds, at first reading, to be a relatively simple job - but it’s not. Julie Sharp, from Deakin University, states, “We were interested to examine the protein’s structure and characteristics to find out exactly what part of the protein was doing what.” In the laboratory, the scientists replicated the platypus milk protein responsible for its antibacterial powers and gave it a long, hard inspection. Their results were recently published in the journal Structural Biology Communications. They wanted to examine the almighty prowess of platypus milk and attempt to understand why it’s so potent. Recently, a team of researchers from Australia’s Commonwealth Scientific and Industrial Research Oganization (CSIRO) combined forces with Deakin University in Victoria, also in Australia. ![]() The authors report that proteins in their milk “were effective in killing a broad range of bacterial pathogens.” So, how on earth could such a natural oddity help to save the human race from the horrors of antibiotic resistance? Well, the answer might lie in its milk.Īccording to an earlier study, platypus milk contains unique antibacterial properties. O.K., I think I’ve adequately emphasized just how unusual the platypus is. Also, baby platypuses are born with teeth, but, at an early age, they all fall out, leaving a horny plate. The strangeness doesn’t stop there, however the female has two ovaries - no surprise - but only the left one actually works. She has a duck-like bill and a beaver-like tail, and she is one of the very few venomous mammals. She’s hairy and warm-blooded, similar to standard mammals, yet she lays eggs. The former is one of the most iconic and baffling animals on the planet. Platypuses are monotremes - that is, a subgroup of mammals that comprises just five species (the platypus and four species of the hedgehog-like echidna). The platypus needs no introduction, but I’ll give you one anyway because they’re just so pleasing to consider.
0 Comments
![]() You may not overtake other vehicles (except bicycles, mopeds and motorcycles) These are some commonly-used regulatory signs in Germany: Both prohibitive and prescriptive regulatory signs are ended by a black-and-white sign (although there are some exceptions). ![]() A red circle is prohibitive (meaning you should not do the action depicted) while a blue circle is prescriptive (meaning you should follow the action depicted). Like speed limit signs, most regulatory signs in Germany are round. They are orders rather than suggestions, and as such must be adhered to. ![]() Regulatory signs are signs that give mandatory orders - for instance things that you should or should not do. Maximum (or recommended) speed limits for urban areas, federal highways and motorways The displayed speed limit only applies to the indicated lane(s)Įnd of all route-related speed and passing restrictions statutory speed limit now applies You must travel at this speed or faster, unless the weather, road or traffic conditions make it necessary to drive slower You are entering an area where the speed limit applies to all roads until you pass an “End of speed limit zone” sign Here are some speed limit signs you will see in Germany:ĭo not exceed the stated speed limit (km/h) Speed limits are ended with a black and white sign - meaning the statutory speed limit now applies. However, Germany also has a minimum speed limit sign (a blue circle), which is most commonly found on the German autobahn. The maximum speed limit sign comprising a number within a red circle will be recognisable to most road users. Speed limit signs in Germany state the maximum speed in kilometres per hour (km/h). Use dipped headlights be prepared to brake suddenly Oncoming traffic may be unexpected, for instance if exiting a one-way street This area frequently has traffic jams prepare to slow down or stop There may be workers, machinery or dirt on the road No right-of-way at next intersection yield to traffic from the right There is an unguarded riverbank or landing ahead The road surface makes sudden manoeuvring, braking or accelerating unsafe Watch out for rocks on the road do not stop or park They usually contain an internationally-recognised black pictogram describing the danger: Warnings signs in Germany are equilateral triangles with a thick red border and white background. Warning signs give advance warning of hazards on or near the road. Motorcycles (includes motorcycles, motorcycles with sidecars, and mopeds)įarm & Power equipment (top speed <25 km/h) Vehicles over 3,5 tonnes (includes trailers and other vehicles that do not qualify as passenger vehicles, NOT buses) Passenger vehicles (cars and light trucks) ![]() Here’s an overview of these symbols, their meanings, and associated subclasses: Symbol For instance, the “motor vehicles” symbol indicates that the sign applies not only to cars but also trucks, motor homes, buses, vehicles with trailers, and so on. Some symbols also include other types of vehicle as well. Traffic signs in Germany use a set of standard symbols to indicate the type or class of vehicle being referred to on the sign. We have included the most important signs from the road sign catalogue ( Verkehrszeichenkatalog) of 2017, along with some new signs from 2020. Officially, signs in Germany are divided into four main categories:įor ease of understanding, this page has grouped the signs slightly differently, into more logical categories. In the official German traffic code, all signs are assigned a unique number, which is used by the police on tickets and reports if a sign is involved in an incident. The German sign system is regularly updated to keep pace with changes in traffic and transportation the last time it had a major overhaul was in the early 1990s. All road signs in Germany have standardised shapes and colours and use easy-to-understand pictograms and symbols that conform closely to European standards. The traffic sign system in Germany is comprehensive and uniform. No matter whether you’re learning to drive in Germany for the first time, need to take an exam to change your driving licence, or just need to brush up on your knowledge before coming to the federal republic for a visit, this page contains an overview of all the most important German road signs. There are over 1.000 traffic signs in the German traffic code, including warning signs, speed limit signs and information signs. If you’re going to be driving in Germany, it’s a good idea to get to grips with the different road signs and their meanings, before hitting the road. ![]() No one knows when they’re going to happen! However, you can bet that your dog will get sick at least once in its lifetime. This is because it is much more difficult to budget for illnesses and accidents. For instance, emergency vet bills are not included-only preventative ones. There were a few things that we didn’t include in our monthly budget. Luckily, much of the higher costs are completely under your control. ![]() ![]() This is extremely expensive and can easily raise your costs much higher than you anticipated. For instance, hiring a dog walker to walk your dog 5 days a week will add up to $400 to your bills on average. Typically, owners on the higher end of this range either live in very expensive places (which leads to higher vet bills), or they depend on more services. However, some people may find themselves spending closer to $600 a month. This includes your dog’s preventative vet bills, food, grooming, and toys. Most people will pay around $100 a month for their Westie. You should budget for supplies alongside the price of a puppy. While some supplies may be able to wait a week or two, there are many things that the dog will need before they even walk through the door.Ĭonsider all of these one-time costs before committing to adopting a dog. You’ll need to purchase things like a dog bed and leash. You also have to consider all the things your dog needs upon arriving at your home. If you choose a high-quality breeder as we recommend, you can expect to pay about $800 to $3,000 for a puppy. This can vary widely depending on where you get the dog. Of course, you have the actual price tag of the puppy. When you bring your puppy home, there are a few one-time costs you’ll need to consider. West Highland White Terrier Price: One-Time Costs We’ll help you budget for these loveable dogs below. All of these things usually end up costing just as much as the puppy, if not more. They will also require regular expenses throughout the year, including food costs and vet bills. Your Westie puppy will need supplies the second you bring them home, like a new collar and dog bed. However, you also need to take their overall cost into account. They simply cost less to breed, and those savings get passed onto you. Much of these savings are due to their smaller size. When compared to most purebred dogs, this is actually quite inexpensive. You can find puppies available for between $800 to $3,000 when you purchase from a breeder. The price tag on a Westie puppy usually isn’t that expensive. However, before you rush out to buy one, it is important to consider the overall cost of these adorable dogs. They make great dogs for active families with or without children. We are happy to say that we do not adopt our puppies to brokers, breeders, or pet stores.Īll of our puppies are lovingly placed into private homes.Westies are fluffy, white dogs with active personalities. Since 1973 we have devoted ourselves to the health, temperament and conformation of our dogs.įor those of you who do not already know, we are in Brighton ( Denver), Colorado.įor our driving clients in Nebraska, Iowa, Kansas or further east, we can meet you in Ogallala, NE - or if "flying private" (Searle Field - OGA) for Nebraska and (Rocky Mtn. We have 50 years of experience (the past 27 years with our Westies) with breeding, raising, and training dogs. Contact us and together let’s find a great match for you and your family. With over 27 years of Westie experience, less than 1% health issues, and, according to our clients, the highest IQ Westies they’ve ever owned. Congratulations! Your search has led you to find the perfect Westie to become a new member of your family. Choose from the included 51 different accompaniment styles (Swing, Ballad, Gypsy Jazz, Bluegrass, Country, Rock, Funk, Reggae, Bossa Nova, Latin.Have a virtual band accompany you as you practice It simulates a real-sounding band that can accompany you as you practice. License transfer between Android, iPhone/iPad or Mac More Transposition. iReal Pro offers an easy-to-use tool to help musicians of all levels master their art. Practice with a realistic sounding piano (or guitar), bass and drum accompaniments for any downloaded or user-created chord chart. Getting started Using iReal Pro on multiple devices. Used by thousands of music students, teachers and some of the world’s top music schools such as Berklee College of Music and Musicians Institute.Ĭreate, edit, print, share and collect chord charts of your favorite songs for reference while practicing or performing. “Now every aspiring musician has a backup band in their pocket.“ – Tim Westergren, Pandora Founder Si tiene problemas para descargar IReal Pro, comparta sus problemas en nuestros foros. One of Time Magazine's 50 Best Inventions of 2010. Descargar IReal Pro para PC (Windows/Mac OS) Para instalar la aplicación IReal Pro en su PC (Windows 10/8/7), siga nuestra guía sobre el uso de Bluestacks para ejecutar archivos APK en su computadora. ![]() The app also lets you create and collect chord charts of your favorite songs for reference. You can get this free update now on the iOS App Store, Mac App Store and Google Play. Open Google Play and in the My Apps section look for updates to iReal Pro. It simulates a real-sounding band that can accompany you as you practice. If you purchased iReal Pro in the Mac App Store updates should appear there. ![]() iReal Pro offers an easy-to-use tool to help musicians of all levels master their art. View your KDP Reports at or by clicking Reports in the menu at the top of the page. Get an overview of each report/tool below along with links that provide more details on each report. Find additional data using the reports and tools in the menu on the left side of the dashboard. You can also view and download your top-earning books, formats, and marketplaces. The KDP Reports Dashboard shows you a snapshot of today’s estimated royalties, sales, and Kindle Edition Normalized Pages (KENP) read. ![]() Topic 8 - Format Your Paperback Manuscript.Topic 5 - Build Your Amazon Detail Page.HTML and CSS Tags Supported in Kindle Format 8.Attributes and Tags Supported by Enhanced Typesetting.Creating Kindle Editions with Audio/Video Content. ![]()
![]() Docker scrutiny is already a member of the group “ disk” so technically there should not be a problem but it does not get permission to get to the hardware. and (2) scrutiny retrives SMART data only in full access mode otherwise it will generate similar error as above. So important here is to set device type sat and do not leave it auto. Time="" level=info msg="Sending detected devices to API, for filtering & validation" type=metrics Time="" level=error msg="Could not retrieve device information for sda: exit status 2" type=metrics ![]() Time="" level=info msg="Executing command: /usr/sbin/smartctl -info -json -dev auto -device sntrealtek /dev/sda" type=metrics Time="" level=info msg="Executing command: /usr/sbin/smartctl -scan -json -dev auto" type=metrics I could see while debuging that auto device type was selecting sntrealtek automatically internally and log was generatting following error time="" level=info msg="Verifying required tools" type=metrics Finally after debugging a lot and entering inside grafana’s container, I managed to get smart data from scrutiny as below (no wonder I see my SMART data failed as there was some issue but I rectified it now.) I am using HA on Rpi-4b model and SSD is connected through NVMe enclosure (Realtek RTL9210B chip) so now learned that scrutiny (full access) works just fine on Rpi-4.Ĭouple of important things, I’d like to mention here to get scrutiny working: (1) My SSD enclosure chip is Realtek RTL9210B so scrutiny (as per smartmontools) I should get SMART data if I set smartctl_command_device_type to auto or sntrealtek but it does not work that way probably because old kernel does not support. It goes on to add, among other things, that support for Office 2016 was meant to be for only five years and these are going to run out in less than two months and a half from now. In fact, most online help content will be retired.“ Key Features Octa-core Apple M1 Chip Processor RAM: 8GB Internal storage: 256 GB Storage Type: SSD Operating system: MacOS Microsoft office included: No. No further updates to support content will be provided.Redesigned Ribbon and New Task Panes All the power of Office. You’ll no longer receive phone or chat technical support. Office design now fully optimized for the Mac, including Retina display and full screen view.Please prepare the following items prior to logging into Editorial Manager. ![]() Security updates are what help protect your Mac from harmful viruses, spyware, and other malicious software. The Editorial Office can verify if you have an existing account. You’ll no longer receive security updates.By Tom Warren, a senior editor covering Microsoft, PC gaming, console, and tech. You’ll no longer receive Office 2016 for Mac software updates from Microsoft Update. Microsoft is releasing an update for Office for Mac 2011 to bring Retina display support.But here’s what the end of support means for you: In the list of updates, locate and select KB4484171, and then select Uninstall. Enter windows update, select Windows Update, and then select Installed Updates. If you're using a mouse, point to the lower-right corner of the screen, and then select Search. Rest assured that all your Office 2016 apps will continue to function-they won’t disappear from your Mac, nor will you lose any data. Swipe in from the right edge of the screen, and then select Search. After installing it however the apps still opened in non-retina mode. “ Support for Office 2016 for Mac will end on October 13, 2020. Today Microsoft released a Retina update for the entire Office for Mac suite. ![]() (Curiously, it is the same day as the EOL of Office 2010 for Windows.) More about the EOL of Office 2016 for Mac here: ![]() Just select one of the Chinese voice text to speech generators and let it read out text in English. In addition to creating text to speech Mandarin, you can use our online chinese text to speech voices as a chinese accent generator for English, as if a typical person from China would pronounce English words. Cantonese Chinese text to speech voices.Taiwanese Mandarin Chinese text to speech voices.Additional Chinese Text to Speech voicesįor more regional Chinese text-to-speech variants, check out the following pages: In addition to these voices, Narakeet has 700 text-to-speech voices in 90 languages.įor more options (uploading Word documents, voice speed/volume controls, working with Powerpoint files or Markdown scripts), check out our Tools. Play the video below (with sound) for a quick demo. Narakeet has 30 Mandarin Chinese text to speech male and female voices, and many more in other regional Chinese variants. You will regularly see people try to troll the text to speech with funny messages that either break the bot or say something. The message is usually read out by a robot, Siri style voice. It allows people to donate money or bits and have a message read out on stream. Get started free with our Chinese text to speech – check out the instructions below. Text to speech is a popular feature on streaming platforms like Twitch. Just upload a Word document or a Powerpoint presentation, and our online Chinese text to speech software will turn your script into a Chinese voice. There’s no programming knowledge required. Narakeet uses the best text to speech software with natural voices for the Mandarin Chinese accent generators. Our text to speech Mandarin voices are realistic and lifelike, helping you produce Chinese MP3 files and MP4 videos much faster than recording the audio yourself. Text to speech Chinese voices make it easy to create online videos, voice overs and audio materials for the Chinese market. ![]() Try our Mandarin Chinese text to speech free online. Easily convert text to speech in Mandarin Chinese, and 90 more languages. Others have concluded that such ratios are too nonspecific and are insensitive to individual fatty acid levels. Some researchers propose that the relative intakes of omega-6s and omega-3s-the omega-6/omega-3 ratio-may have important implications for the pathogenesis of many chronic diseases, such as cardiovascular disease (CVD) and cancer, but the optimal ratio-if any-has not been defined. Thus, higher concentrations of EPA and DHA than arachidonic acid tip the eicosanoid balance toward less inflammatory activity. Similarly, EPA and DHA can compete with arachidonic acid for the synthesis of eicosanoids. Because both classes of fatty acids compete for the same desaturation enzymes, ALA is a competitive inhibitor of linoleic acid metabolism and vice versa. The eicosanoids made from omega-6s are generally more potent mediators of inflammation, vasoconstriction, and platelet aggregation than those made from omega-3s, although there are some exceptions. Eicosanoids are signaling molecules that have similar chemical structures to the fatty acids from which they are derived they have wide-ranging functions in the body's cardiovascular, pulmonary, immune, and endocrine systems. In addition to their structural role in cell membranes, omega-3s (along with omega-6s) provide energy for the body and are used to form eicosanoids. DHA, in particular, is especially high in the retina, brain, and sperm. Omega-3s play important roles in the body as components of the phospholipids that form the structures of cell membranes. Once in the bloodstream, lipoprotein particles circulate within the body, delivering lipids to various organs for subsequent oxidation, metabolism, or storage in adipose tissue. Within intestinal cells, free fatty acids are primarily incorporated into chylomicrons and enter the circulation via the lymphatic system. The process is efficient, with an absorption rate of about 95%, which is similar to that of other ingested fats. The hydrolysis products-monoglycerides and free fatty acids-are then incorporated into bile-salt– containing micelles and absorbed into enterocytes, largely by passive diffusion. Īfter ingestion, dietary lipids are hydrolyzed in the intestinal lumen. When fish consume phytoplankton that consumed microalgae, they accumulate the omega-3s in their tissues. DHA and EPA are present in fish, fish oils, and krill oils, but they are originally synthesized by microalgae, not by the fish. Therefore, consuming EPA and DHA directly from foods and/or dietary supplements is the only practical way to increase levels of these fatty acids in the body.ĪLA is present in plant oils, such as flaxseed, soybean, and canola oils. ALA can be converted into EPA and then to DHA, but the conversion (which occurs primarily in the liver) is very limited, with reported rates of less than 15%. Therefore, ALA and linoleic acid are considered essential fatty acids, meaning that they must be obtained from the diet. The human body can only form carbon–carbon double bonds after the ninth carbon from the methyl end of a fatty acid. Linoleic acid (C18:2n-6) and arachidonic acid (C20:4n-6) are two of the major omega-6s. Omega-6 fatty acids (omega-6s) have a carbon–carbon double bond that is six carbons away from the methyl end of the fatty acid chain. Similarly, EPA is known as C20:5n-3 and DHA as C22:6n-3. ![]() ALA, for example, is known as C18:3n-3 because it has 18 carbons and 3 double bonds and is an n-3, or omega-3, fatty acid. PUFAs are frequently designated by their number of carbon atoms and double bonds. ALA contains 18 carbon atoms, whereas EPA and DHA are considered long-chain (LC) omega-3s because EPA contains 20 carbons and DHA contains 22. Several different omega-3s exist, but the majority of scientific research focuses on three: alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Omega-3s, sometimes referred to as n-3s, are present in certain foods such as flaxseed and fish as well as dietary supplements such as fish oil. ![]() Omega-3 fatty acids (omega-3s) have a carbon–carbon double bond located three carbons from the methyl end of the chain. PUFAs are distinguished from saturated and monounsaturated fatty acids by the presence of two or more double bonds between carbons within the fatty acid chain. Like all fatty acids, PUFAs consist of long chains of carbon atoms with a carboxyl group at one end of the chain and a methyl group at the other. The two major classes of polyunsaturated fatty acids (PUFAs) are the omega-3 and omega-6 fatty acids. For a general overview, see our consumer fact sheet. This is a fact sheet intended for health professionals. ![]() West expects the canned cocktail trend to continue to grow, notably at the expense of beer. Sales of High Noon rose nearly 100% last year, making it the top-selling spirit-based canned cocktail, according to data from IRI, a Chicago-based market research firm Meanwhile, Truly and Bud Light Seltzer sales each dropped roughly 20%. So far, sales of High Noon’s seltzers are growing faster compared to malt-based seltzers such as Bud Light Seltzer. “Consumers were gravitating toward these products that had functional attributes, such as being under 100 calories with zero carbs and zero sugar,” West said. Gallo jumped on the canned cocktail craze in 2019 with High Noon, a vodka base mixed with several types juice including lime, lemon and mango. In the early 2000s, Gallo expanded its spirits lineup to include New Amsterdam vodka and it currently sells a variety of alcohols, including tequila and scotch whiskey. Its first spirit was brandy, a no-brainer for a winery, which it began selling in the 1970s. ![]() Gallo Winery, an 89-year-old company that makes well-known wines such as Barefoot, Carlo Rossi and Manischewitz kosher wine. He described the taste as a “fairly light delivery” without the punchy bite of a typical tequila drink. However, West said that his brand has the first seltzer that simply mixes tequila with juice without added sugar. Canned margaritas are popular with other brands, such as Cutwater Spirits and Cazadores Tequila. “Ranch Water,” a combination of tequila, lime juice and Topo Chico, has proven successful for Molson Coors’ Topo Chico-branded seltzer lineup. Or course, High Noon Tequila Seltzer isn’t the first tequila-based premixed cocktail. Sales of the former shot up nearly 36% and the latter rose 17%.Īdding tequila to High Noon’s portfolio could help expand the company’s base because a “tequila consumer is often not a vodka consumer so we felt there was an undeserved market for people who would want a real spirit and real juice tequila-based product,” West said. The numbers back that up: Premixed cocktails and tequila were the two fastest growing categories by revenue in 2022, according to a recent report from Distilled Spirits Council of the United States. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |